Happy New Year!

2018 was a fantastic year for ThromboLUX as we set a new high-water mark for the number of ThromboLUX tests conducted in a year, 8,450 to be exact. We are excited to work towards helping even more blood banks characterize their platelets in 2019, but first, we want to start a new annual tradition of recapping the platelet activation status statistics from across the US for the previous year. The data for the 2018 recap comes from 4 hospitals and 1 blood distributor.

Overall Platelet Activation Rates

The Platelet Activation Rate is the percentage of platelet units which are classified by ThromboLUX as activated. This year we saw a 35% activation rate.

2018 Activation Rate

Figure 1 – Overall activation rate average for all units tested in 2018

Platelet Activation by Supplier and Apheresis Machine

For a long time, we’ve known that the activation rates varied significantly between suppliers. During 2018 we learned that a major contributor to the variability is the apheresis machine used to collect the platelets. We’ve found that platelets produced on Trima Accel are much less likely to be activated than platelets produced on Amicus. Below you can see the activation rates and which apheresis collection technology was used for all suppliers with over 100 ThromboLUX tests.

Platelet Activation Rate - 8 US Suppliers

Figure 2 – Platelet activation rate for all suppliers with more than 100 ThromboLUX tests conducted in 2018.

As mentioned above there is a clear difference in activation rate between Trima Accel-produced platelets and Amicus-produced platelets. In Figure 2 above we see the sole supplier to use Amicus platelets exclusively is the only supplier to produce activated platelets more than half of the time. The supplier with the next highest activation rate was the regional supplier (shown on the far right in the chart above) that used both Amicus and Trima Accel.

Figure 3 below shows a direct comparison of all Trima Accel and Amicus platelets tested in 2018. Using a Pearson Chi-squared test we determined the difference is statistically significant (p< 0.001). In this analysis, we did not control for all known variables, for example, supplier, and product age, however, an analysis taking those factors into account is underway.

Platelet Activation Rate by Apheresis Technology

Figure 3 – Direct comparison of Trima Accel and Amicus platelet activation rates.

Platelet Activation Rates by Day

Below are the Platelet Activation Rates by day for the 4 hospitals included in this year’s data set. As you can see there is a lot of variability between days within each hospital as well as significant differences in the average activation rates across the hospitals. This difference in activation rate is driven by the differences between blood suppliers.

Daily Hospital Platelet Activation Rates by Day

Figure 4 – The daily activation rates from 4 hospitals in the US during 2018

Share your views – leave a comment

See anything that raises a question, or have some relevant information to share with us? Let all readers learn by posting a comment below.

If you are interested in understanding the activation rate of your platelet inventory as these hospitals have done, you can send us a message through the Contact page.